#5907 RENAL INJURY IN RELATION TO OBESITY AND THE ADDITIVE EFFECT OF HYPERTENSION IN FEMALE AND MALE OBESE AND LEAN ZSF1 RATS

Abstract Background and Aims Chronic kidney disease co-exists with heart failure preserved ejection fraction (HFpEF), which is characterized by the presence of obesity, hypertension, diabetes mellitus type 2. Obese ZSF1 rats, a model HFpEF, exhibit multiple these comorbidities that can disturb cardiac function. Little attention has been paid to how affect renal in rats. HFpEF found predominantly women whom obesity hypertension are particularly prevalent. Therefore, we aimed characterize phenotype female male, lean obese, rats investigated additional effects worsened on severity. Method Systolic blood pressure function were assessed biweekly from 12 26 weeks age tail-cuff plethysmography, urine collection via metabolic cages plasma collection, respectively. From 19 age, implanted either deoxycorticosterone acetate pellet (DOCA) fed high salt diet (6% NaCl) or placebo normal diet. At terminal GFR was inulin clearance under isoflurane. Renal sections processed for histological analysis. Results Lean obese both mildly hypertensive (systolic 140-150 mmHg). All showed evidenced elevated E/e’ ratio. In normoglycemic associates mild proteinuria, decreased glomerular hypertrophy. The addition DOCA-salt but not their counterparts. DOCA-salt-worsened enhanced proteinuria triggered glomerulosclerosis Male hyperglycemic hypertrophy sclerosis, tubulo-interstitial damage. male further aggravated damage, sclerosis No effect observed Conclusion Female developed deteriorated structure similar